Estudios sobre CBD

Cada vez hay estudios más prometedores sobre el CBD. En este post, recopilamos algunos y los separamos por temáticas.

Estudios generales sobre CBD

A continuación tienes el informe de la Organización Mundial de la Salud, pero si prefieres ver un resumen, puedes pinchar aquí:

• Cannabidiol (CBD) Pre-Review Report: Expert Committee on Drug Dependence;Thirty ninth Meeting; Geneva, November 6-10, 2017; World Health Organization. Descarga: https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf
• Safety and side effects of cannabidiol, a Cannabis sativa constituent. Sept 2011. Mateus Machado, Regina H. Costa Queiroz, Antonio W. Zuardi, José A. S. Crippa. Department of Clinical, Toxicological and Food Sciences Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, SP, Brazil. https://pubmed.ncbi.nlm.nih.gov/22129319/

Aumento de la concentración & CBD:

• Cannabinoids in attention-deficit/hyperactivity disorder: A randomised-controlled trial; European Neuropsychopharmacolology; May 30, 2017; Cooper RE, Williams E, Seegobin S, Tye C, Kuntsi J, Asherson P; https://www.ncbi.nlm.nih.gov/pubmed/28576350
• Modulation of cognitive and emotional processing by cannabidiol: the role of the anterior cingulate cortex; Frontiers in Human Neurosciences; Apr 18, 2013; Mikael A. Kowal, Arno Hazekamp, Lorenza S Colzato, Henk van Steenbergen, and Bernhard Hommel; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629308/
• Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial; Cannabis and Cannabinoid Research; March 1, 2018; Nadia Solowij, Samantha J. Broyd, Camilla Beale, Julie-Anne Prick, Lisa-marie Greenwood, Hendrika van Hell, Chao Suo, Peter Galettis, Nagesh Pai, Shanlin Fu, Rodney J. Croft, Jennifer H. Martin, and Murat Yücel; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870061/

Ansiedad, estrés, depresión & CBD

• Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials; Frontiers in Neuroscience; July 24, 2018; Rafael M. Bitencourt and Reinaldo N Takahashi; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066583/
• Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders; Philosophical Transactions of The Royal Society B Biological Sciences; Dec 5, 2012; Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS; https://www.ncbi.nlm.nih.gov/pubmed/23108553/
• Cannabidiol as a Potential Treatment for Anxiety Disorders; Neurotherapeutics; September 4, 2015; Esther M Blessing, Maria M. Steenkamp, Jorge Manzanares, and Charles R Marmar; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/
• Evidences for the Anti-panic Actions of Cannabidiol; Current Neuropharmacology; February 2017; Vanessa P Soares and Alline C Campos; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412699/

Mejora del humor & CBD

• Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors; Neuropharmacology; December 19, 2015; Linge R, Jiménez-Sánchez L, Campa L, Pilar-Cuéllar F, Vidal R, Pazos A, Adell A, Díaz Á; https://www.ncbi.nlm.nih.gov/pubmed/26711860

Dolores e inflamación & CBD

• Cannabinoids in the management of difficult to treat pain; Therapeutics and Clinical Risk Management; February 4, 2008; Ethan B Russo; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
• Cannabinoid Delivery Systems for Pain and Inflammation Treatment; Molecules; September 27, 2018; Natascia Bruni, Carlo Della Pepa, Simonetta Oliaro-Bosso, Enrica Pessione, Daniela Gastaldi, and Franco Dosio; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222489/
• Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes. 28 Jul 2016; Ethan B Russo; https://www.liebertpub.com/doi/10.1089/can.2016.0009
• Adding medical cannabis to standard analgesic treatment for fibromyalgia: a prospective observational study. Jan-Feb 2020. Valeria Giorgi  , Sara Bongiovanni, Fabiola Atzeni, Daniela Marotto , Fausto Salaffi, Piercarlo Sarzi-Puttini. https://pubmed.ncbi.nlm.nih.gov/32116208/
• Cannabinoids for fibromyalgia. 2016 Jul 18. Brian Walitt, Petra Klose, Mary-Ann Fitzcharles, Tudor Phillips, Winfried Häuser. National Center for Complementary and Integrative Health, National Institutes of Health, 10 Center Drive, Bethesda, MD, USA. https://pubmed.ncbi.nlm.nih.gov/27428009/
• Cannabinoids and Pain: New Insights From Old Molecules. Nov 2018. Sonja Vučković^1*, Dragana Srebro, Katarina Savić Vujović, Čedomir Vučetić and Milica Prostran.Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.12309

Dolores menstruales & CBD

• The Clinical Significance of Endocannabinoids in Endometriosis Pain Management; Cannabis and Cannabinoid Research; April 1, 2017; Jerome Bouaziz, Alexandra Bar On, Daniel S. Seidman, and David Soriano; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436335/

Sueño & CBD

• No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study; Frontiers in Pharmacology; April 5, 2018; Ila M P Linares, Francisco S Guimaraes, Alan Eckeli, Ana C S Crippa,Antonio W Zuardi, Jose D S Souza, Jaime E Hallak, and José AS Crippa; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895650/
• Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson’s disease patients: a case series; Journal of Clinical Pharmacy and Therapeutics, May 21, 2014; Chagas MH1, Eckeli AL, Zuardi AW, Pena-Pereira MA, Sobreira-Neto MA, Sobreira ET, Camilo MR, Bergamaschi MM, Schenck CH, Hallak JE, Tumas V, Crippa JA; https://www.ncbi.nlm.nih.gov/pubmed/24845114

Piel

• Antioxidative and Anti-Inflammatory Properties of Cannabidiol; 2019 Dec 25; Department of Analytical Chemistry, Medical University of Białystok, 15-089 Białystok, Poland. https://pubmed.ncbi.nlm.nih.gov/31881765/
• Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes; Lendület” Cellular Physiology Research Group, Department of Physiology, University of Debrecen, Debrecen, Hungary. Laboratory for Ion Channel Research and TRP Research Platform Leuven, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium. Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan. Department of Dermatology, University of Lübeck, Lübeck, Germany. Neurobiology Research Group, Department of Physiology, University of Debrecen, Debrecen, Hungary. Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy. Departments of Dermatology, Venereology, and Allergology and Immunology, Dessau Medical Center, Dessau, Germany. School of Translational Medicine, University of Manchester, Manchester, United Kingdom https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151231/
• A Therapeutic Effect of Cbd-Enriched Ointment in Inflammatory Skin Diseases and Cutaneous Scars; Mar-Apr 2019. Palmieri B, Laurino C, Vadalà M. Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena – Second Opinion Medical Network, Modena (MO), Italy. https://pubmed.ncbi.nlm.nih.gov/30993303/
• Anti-inflammatory Properties of Cannabidiol, a Nonpsychotropic Cannabinoid, in Experimental Allergic Contact Dermatitisocytes; Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli, Napoli, Italy (S.P., R.V., M.A., V.D.); Epitech Group SpA, Saccolongo, Padova, Italy (S.P., M.A.); and Dipartimento di Farmacologia Sperimentale, Università di Napoli “Federico II”, Napoli, Italy (M.V., T.I.). https://pubmed.ncbi.nlm.nih.gov/29632236/
• Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis; February 2007; Journal of Dermatological Science. https://www.sciencedirect.com/science/article/abs/pii/S092318110600315X
• The potential role of cannabinoids in dermatology. Oct 2019. Tabrez Sheriff, Matthew J Lin, Danielle Dubin, Hooman Khorasani. The Royal Prince Alfred Hospital , Sydney , Australia and Icahn School of Medicine at Mount Sinai , New York , NY, USA. https://pubmed.ncbi.nlm.nih.gov/31599175/

Animales y CBD

• Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs. 2018. Gamble L-J, Boesch JM, Frye CW, Schwark WS, Mann S, Wolfe L, Brown H, Berthelsen ES and Wakshlag. https://www.frontiersin.org/articles/10.3389/fvets.2018.00165/
• Pharmacokinetics of cannabidiol administered by 3 delivery methods at 2 different dosages to healthy dogs. 2018. Lisa R Bartner , Stephanie McGrath, Sangeeta Rao, Linda K Hyatt, Luke A Wittenburg. Department of Clinical Sciences, Colorado State University, USA. https://pubmed.ncbi.nlm.nih.gov/30026641/
• Effects of cannabidiol, a Cannabis sativa constituent, on oral wound healing process in rats: Clinical and histological evaluation. Nov 2018. Mariana Klein, Juliane de Quadros, Francisco Silveira, Fernanda Gonçalves, Karen Cherubini, Maria Antonia Zancanaro. Pontifical Catholic University of Rio Grande do Sul & Faculty of Medicine of Ribeirão Preto, Brazil. https://pubmed.ncbi.nlm.nih.gov/30088305/
• Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats. Kelly A Deabold, Wayne S Schwark, Lisa Wolf, Joseph J Wakshlag. University of Florida College of Veterinary Medicine & Cornell College of Veterinary Medicine & Colorado State University, USA. https://pubmed.ncbi.nlm.nih.gov/31635105/